Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add filters

Database
Language
Document Type
Year range
1.
Sci Rep ; 12(1): 1360, 2022 01 25.
Article in English | MEDLINE | ID: covidwho-1655615

ABSTRACT

The WHO defines different COVID-19 disease stages in which the pathophysiological mechanisms differ. We evaluated the characteristics of these COVID-19 disease stages. Forty-four PCR-confirmed COVID-19 patients were included in a prospective minimal invasive autopsy cohort. Patients were classified into mild-moderate (n = 4), severe-critical (n = 32) and post-acute disease (n = 8) and clinical, radiological, histological, microbiological and immunological data were compared. Classified according to Thoracic Society of America, patients with mild-moderate disease had no typical COVID-19 images on CT-Thorax versus 71.9% with typical images in severe-critical disease and 87.5% in post-acute disease (P < 0.001). Diffuse alveolar damage was absent in mild-moderate disease but present in 93.8% and 87.5% of patients with severe-critical and post-acute COVID-19 respectively (P = 0.002). Other organs with COVID-19 related histopathological changes were liver and heart. Interferon-γ levels were significantly higher in patients with severe-critical COVID-19 (P = 0.046). Anti-SARS CoV-2 IgG was positive in 66%, 40.6% and 87.5% of patients with mild-moderate, severe-critical and post-acute COVID-19 respectively (n.s.). Significant differences in histopathological and immunological characteristics between patients with mild-moderate disease compared to patients with severe-critical disease were found, whereas differences between patients with severe-critical disease and post-acute disease were limited. This emphasizes the need for tailored treatment of COVID-19 patients.


Subject(s)
Antibodies, Viral/immunology , COVID-19 , Immunoglobulin G/immunology , Pulmonary Alveoli , SARS-CoV-2/immunology , Tomography, X-Ray Computed , Aged , Aged, 80 and over , Autopsy , COVID-19/diagnostic imaging , COVID-19/immunology , COVID-19/pathology , Female , Humans , Male , Prospective Studies , Pulmonary Alveoli/diagnostic imaging , Pulmonary Alveoli/immunology , Pulmonary Alveoli/pathology
SELECTION OF CITATIONS
SEARCH DETAIL